We present a rare case of PML in a patient with autoimmune hemolytic anemia (AIHA). Patients with systemic lupus erythematosus (SLE) and chronic renal failure, being immunosuppressed, seem to be at a greater risk of developing PML, which is associated with a mortality rate of 50% in a few weeks. Disseminated PML is characterized by multifocal involvement of the brain and can occur at any age, although most cases present in the third and fourth decades of life. The most common CNS manifestation of PML is a subcortical lesion with periventricular localization. The rate of PML in patients with immunocompromised conditions is 7.5 times greater than in normal individuals.

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